The issue is related to HTTP Request Smuggling attacks, which can occur when mod proxy is enabled along with certain RewriteRule or ProxyPassMatch configurations. These configurations can allow an attacker to bypass access controls in the proxy server, proxy unintended URLs to existing origin servers, and perform cache poisoning. The vulnerability can be exploited when a non-specific pattern matches some portion of the user-supplied request-target (URL) data and is then re-inserted into the proxied request-target using variable substitution. For example, a configuration like RewriteEngine on RewriteRule "^/here/(.*)" "http://example.com:8080/elsewhere?$1"; [P] ProxyPassReverse /here/ http://example.com:8080/ can be vulnerable. Approximately 33,652,790 results are affected.